Radiobiological evaluation of a newly synthesized cysteamine derivative
A new cysteamine-based compound, I109 (N-glycylglycyl-S acetylcysteamine trifluoroacetate) was tested on both normal tissues and tumors to evaluate its radioprotective potential. I109, which is three times less toxic than WR-2721, was injected at a dose approximately equal to half the LD50(30 days). The Protection Factor (PF = gamma ray dose ratio) after whole body irradiation was 1.3-1.4 for intestinal death and 1.4-1.5 for hemopoietic death when intervals of 40 or 20 min elapsed between injection and the end of irradiation. A crypt cell assay was done for both I109 and WR-2721; PFs were 1.1 and 1.4, respectively. I109 was then tested on five solid tumors. For each cell line (4 human, 1 murine) one dose of radiation was delivered. Surviving fraction ratios with and without drug ranged between 2.4 and 14.1 when an interval of 20 min elapsed between injection and the end of irradiation. The degree of radioprotection proved time dependent for EMT6 and HRT18; radioprotection afforded by WR-2721 on these tumors is either similar or greater than radioprotection afforded by I109 depending on the time interval between injection and irradiation.
- Research Organization:
- Institut Gustave-Roussy, Villejuif, France
- OSTI ID:
- 6933940
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparative study of the radioprotective effects of cysteamine, WR-2721, and WR-1065 in cultured human cells. [Reproductive death of cells following. gamma. irradiation used as indicator]
Chemical protection against gastrointestinal radiation injury in mice by WR 2822, WR 2823, or WR 109342 after 4 MeV x ray or fission neutron irradiation
Related Subjects
MEA
RADIOSENSITIVITY EFFECTS
MICE
NEOPLASMS
RADIOPROTECTIVE SUBSTANCES
WHOLE-BODY IRRADIATION
AMINES
ANIMALS
DISEASES
DRUGS
EXTERNAL IRRADIATION
IRRADIATION
MAMMALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RODENTS
THIOLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals