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Role of Leu-enkephalin in the regulation of carbohydrate metabolism

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
DOI:https://doi.org/10.1007/BF00841802· OSTI ID:6924405
The aim of this investigation was to study the possible role of Leuenkephalin (LE) is the regulation of carbohydrate metabolism. Experiments were carried out on 166 mole albino rats weighing 180-220 g. Opioid peptides, namely LE, D-Ala/sup 2/-Leu/sup 5/-Arg/sup 6/-enkephalin, and d-Ala/sup 2/-D-Leu/sup 5/-D-Arg/sup 6/-enkephalin were injected intraperitoneally in a dose of 500 ..mu..g/kg, naloxone, a blocker of opiate receptors, was injected in a dose of 100 ..mu..g/kg, and the pharmacopoeial preparations Parathyroidin in a dose of 10 U/kg and adrenalin hydrochloride in a dose of 500 ..mu..g/kg. Animals of the control group were given injections of 0.2 ml of physiological saline. The rats were decapitated under superficial ether anesthesia 1 h after injection of the drugs. Insulin levels were determined by radioimmunoassay. Radioactivity was counted on a gamma-spectrometer. The glycogen concentration in the samples was determined spectrophotometrically and the cAMP concentration by radioimmunoassay. Radioactivity was counted on a Mark III scintillation counter.
Research Organization:
All-Union Cardiologic Scientific Center, Tomsk (USSR)
OSTI ID:
6924405
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 103:5; ISSN BEXBA
Country of Publication:
United States
Language:
English

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Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALDEHYDES
AMP
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARBOHYDRATES
CHEMISTRY
CONTROL
COUNTING TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
ENDORPHINS
ENKEPHALINS
GAMMA SPECTRA
GLANDS
GLUCOSE
GLYCOGEN
HEXOSES
HORMONES
IMMUNOASSAY
IMMUNOLOGY
INJECTION
INSULIN
INTAKE
INTRAPERITONEAL INJECTION
ISOTOPE APPLICATIONS
LIVER
MAMMALS
MATERIALS
METABOLISM
MONOSACCHARIDES
NEUROREGULATORS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
POLYSACCHARIDES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RATS
RODENTS
SACCHARIDES
SCINTILLATION COUNTING
SPECTRA
SPECTROPHOTOMETRY
THYROID HORMONES
TRACER TECHNIQUES
VERTEBRATES