Mechanism of the antistress action of d-ala/sup 2/-leu/sup 5/-arg/sup 6/-enkephalin

Journal Article · Sat Feb 01 04:00:00 EST 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

OSTI ID:7166205

Lishmanov, Yu B; Maslov, L N; Titov, M I

The authors study the effect of the arginine-containing hexapeptide analog of Leu-enkephalin - D-Ala/sup 2/-Leu/sup 5/-Ar/sup 6/--enkephalin (enkephalin) on blood plasma levels of ACTH, cortisol, and hormones of the pituitary-thyroid complex, and the cAMP concentration in adrenal and thymus tissues during stress induced by crushing the soft tissues (CST). The experiments were carried out on noninbred male albino rats. The plasma ACTH and cortisol levels were determined by radioimmunoassay using kits from France, thyroxine (T/sub 4/) and tri-iodothyronine (T/sub 3/), and pituitary thyrotropic hormone. A gamma-spectrometer and beta-scintillation counter were used.

• Research Organization: Laboratory of Radionuclide Methods of Investigation, Siberian Branch, All-Union Cardiologic Scientific Center, Academy of Medical Sciences of The USSR, Tomsk
• OSTI ID: 7166205
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:9; ISSN BEXBA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
ACTH
ADRENAL GLANDS
ADRENAL HORMONES
AMINO ACIDS
AMP
ANIMAL TISSUES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
COMMINUTION
CORTICOSTEROIDS
COUNTING TECHNIQUES
CRUSHING
DRUGS
ENDOCRINE GLANDS
ENDORPHINS
ENKEPHALINS
GLANDS
GLUCOCORTICOIDS
HORMONES
HYDROCORTISONE
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KETONES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
NEUROREGULATORS
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
PITUITARY HORMONES
POLYPEPTIDES
PREGNANES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RATS
RODENTS
SCINTILLATION COUNTING
STEROID HORMONES
STEROIDS
THYMUS
THYROID HORMONES
THYROXINE
TISSUES
TRACER TECHNIQUES
TRIIODOTHYRONINE
VERTEBRATES