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Indium-111-labeled white blood cells: dosimetry in children

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6924172
; ; ;

The distribution of (/sup 111/In)oxine-labeled leukocytes was studied by whole-body gamma camera imaging in nine pediatric patients. Images were obtained at approximately 24 hr after administration of the material. Organ distribution was estimated from stored data by manual region of interest assignment. Dosimetry estimates based on geometric mean and conjugate view absolute activity calculations showed close agreement in these patients. Leukocytes were distributed in liver, spleen and marrow. The mean percent uptakes +/- s.d. were: spleen, 31.2 +/- 18.3%; liver, 26.3 +/- 10.8%; and marrow, 14.2 +/- 5.7%. A significant portion (28.3 +/- 9.9%) of administered white cell activity was found outside these organs in the remainder of the body. Mean organ absorbed doses (rad/mCi) were: spleen, 115.0 +/- 84.8; liver, 13.9 +/- 7.8; marrow, 7.6 +/- 3.8; and total body 2.5 +/- 1.0. The mean organ absorbed doses (rad/dose administered) were: spleen, 13.7 +/- 10.6; liver, 1.48 +/- 0.62; marrow, 0.79 +/- 0.26; and total body, 0.28 +/- 0.09.

Research Organization:
St. Christopher's Hospital for Children, Philadelphia, PA (USA)
OSTI ID:
6924172
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
ANIMAL TISSUES
AROMATICS
AZAARENES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CAMERAS
CHILDREN
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GAMMA CAMERAS
GLANDS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMAGE PROCESSING
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLING
LEUKOCYTES
LIVER
MATERIALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXINE
PEDIATRICS
PROCESSING
PYRIDINES
QUINOLINES
RADIOISOTOPES
SPLEEN
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
WHOLE-BODY COUNTING