Distribution and dosimetry of In-111 labeled leukocytes and platelets in humans

Conference · Mon Jun 01 04:00:00 EDT 1981 · HHS Publ. (FDA) (U.S.); (United States)

OSTI ID:5919838

Goodwin, D A ^[1]; Finston, R A; Smith, S I

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1. Veterans Administration Medical Center, Palo Alto, CA

The distribution of In-111 labeled leukocytes and platelets was studied by whole body gamma camera imaging in patients. Images were made approximately one hour and 24 hours after IV injection, and stored in digital form in computer memory. Estimates of the quantitative organ distribution were made from the geometric mean of the anterior and posterior region of interest counts after suitable background subtraction. Nearly quantitative retention of cell activity was observed with little or no excretion seen in either gut or kidneys. Mixed leukocytes distributed in spleen, liver and bone marrow in decreasing order of concentration, similar at both times, with a transient lung uptake noted at the one hour time only. The dose from 0.5 mCi In-111-WBC's was: liver, 1.4 rad; spleen, 8.5 rad; marrow, 2.3 rad. Lymphocytes had similar distribution with the addition of inguinal and cervical lymph nodes. The dose from 0.5 mCi In-111-lymphocytes was: liver, 0.8 rad; spleen, 6.7 rad; marrow and lymphatic tissue, 1.4 rad. Platelets distributed primarily in the blood pool with most of the remainder concentrating in the spleen, with a small amount in the penis. The dose from 0.5 mCi of In-111-platelets was: liver, 3.2 rad; spleen, 8.6 rad; and whole body, 0.3 rad.

• OSTI ID: 5919838
• Report Number(s): CONF-801082-
• Conference Information: Journal Name: HHS Publ. (FDA) (U.S.); (United States) Journal Volume: 81-8166
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCURACY
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CAMERAS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DISTRIBUTION
DOSES
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
GAMMA CAMERAS
IMAGES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
PATIENTS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIOISOTOPES
RADIONUCLIDE KINETICS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
USES