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Distribution and dosimetry of /sup 111/In-labeled platelets

Conference · · Radiology; (United States)
OSTI ID:6188018
; ; ; ;

The distribution of /sup 111/In-labeled platelets was studied in five young, healthy men. The radioactivity in the lungs, heart, liver, spleen, kidneys, and testes was determined from areas-of-interest in computed gamma-camera scans at intervals up to 75 hours after injection. After the first four hours, the activity in each organ studied except the liver and kidney decreased at roughly the physical decay rate. In the liver and kidney, the curves were relatively flat, indicating continued accumulation of the radiotracer. The calculated mean radiation absorbed dose per unit administered activity was 0.60 rad/mCi for the total body, and was 34 rad/MCi; for the spleen.

Research Organization:
Mayo Clinic/Foundation, Rochester, MN
OSTI ID:
6188018
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 140:1; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560161* -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
CALCULATION METHODS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
DOSIMETRY
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
GONADS
HEART
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
MALE GENITALS
MALES
MAMMALS
MAN
MATERIALS
MEN
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIATION DOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
SCINTISCANNING
SPLEEN
TESTES
TISSUE DISTRIBUTION
VERTEBRATES