Distribution and dosimetry of /sup 111/In-labeled platelets
The distribution of /sup 111/In-labeled platelets was studied in five young, healthy men. The radioactivity in the lungs, heart, liver, spleen, kidneys, and testes was determined from areas-of-interest in computed gamma-camera scans at intervals up to 75 hours after injection. After the first four hours, the activity in each organ studied except the liver and kidney decreased at roughly the physical decay rate. In the liver and kidney, the curves were relatively flat, indicating continued accumulation of the radiotracer. The calculated mean radiation absorbed dose per unit administered activity was 0.60 +/- 0.07 rad/mCi (0.16 +/- 0.02 Gy/GBq) for the total body, and was 34 +/- 6 rad/mCi (9.0 +/- 1.5 Gy/GBq) for the spleen.
- OSTI ID:
- 5405496
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 140:1; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
GAMMA CAMERAS
GAMMA DOSIMETRY
GLANDS
GONADS
HEART
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LIVER
LUNGS
MALE GENITALS
MALES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
SCINTISCANNING
SPLEEN
TESTES
TIME DEPENDENCE
TISSUE DISTRIBUTION
USES