Metal complexes of luteinizing hormone-releasing hormone (LHRH). Potentiometric and spectroscopic studies

Journal Article · Sun May 01 04:00:00 EDT 1988 · J. Inorg. Biochem.; (United States)

DOI:https://doi.org/10.1016/0162-0134(88)80030-8· OSTI ID:6922163

Gerega, K; Kozlowski, H; Masiukiewicz, E; Pettit, L D; Pyburn, S; Rzeszotarska, B

The results are reported of a potentiometric and spectroscopic study of the H+, Cu2+, and Ni2+ complexes of luteinizing hormone-releasing hormone (LHRH, HL) at 25 degrees C and an ionic strength 0.10 mol dm-3 (KNO3), since there is much evidence that the in vivo release of LHRH is influenced by the concentration of copper ions. With Cu2+ the hormone has been shown to behave similarly to the thyrotropin releasing factor, forming a very stable (CuH-1L) complex involving coordination of three nitrogen donors: the Nim atom of the imidazole side chain and the two amido-N atoms of the pyroglutamylhistidyl unit. With Ni2+, coordination proceeds differently to give four nitrogen coordination.

• Research Organization: Univ. of Wroclaw (Poland)
• OSTI ID: 6922163
• Journal Information: J. Inorg. Biochem.; (United States), Journal Name: J. Inorg. Biochem.; (United States) Vol. 33:1; ISSN JIBID
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BARYONS
COMPLEXES
COPPER COMPOUNDS
ELECTRON SPIN RESONANCE
ELEMENTARY PARTICLES
FERMIONS
HADRONS
HORMONES
LH-RH
LIBERINS
MAGNETIC RESONANCE
METABOLISM
NICKEL COMPOUNDS
NUCLEONS
PEPTIDE HORMONES
PITUITARY HORMONES
POTENTIOMETRY
PROTONS
RESONANCE
SPECTROPHOTOMETRY
TITRATION
TRANSITION ELEMENT COMPOUNDS