Clinical laboratory manifestations of exposure to dioxin in children. A six-year study of the effects of an environmental disaster near Seveso, Italy
Journal Article
·
· JAMA, J. Am. Med. Assoc.; (United States)
Following a major environmental accident near Seveso, Italy, on July 10, 1976, we attempted to determine if the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) released into the atmosphere had any effect on the liver function and lipid metabolism of exposed children. From July 1976 to June 1982, we analyzed the results of more than 4500 laboratory tests (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, cholesterol, and triglycerides in plasma and delta-aminolevulinic acid in urine) in a population of about 1500 children aged 6 to 10 years at the moment of the accident. The children exposed to the highest concentration of TCDD showed alterations in serum gamma-glutamyltransferase and alanine aminotransferase activity compared with the control group. These differences were restricted to values inside limits set from the lower end of the normal range to slightly above it. The observed abnormalities were slight and disappeared with time.
- Research Organization:
- Dept. of Clinical Pathology, Milan, Italy
- OSTI ID:
- 6914227
- Journal Information:
- JAMA, J. Am. Med. Assoc.; (United States), Journal Name: JAMA, J. Am. Med. Assoc.; (United States) Vol. 19; ISSN JAMAA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure to humans--Seveso, Italy
Journal Article
·
Mon Oct 31 23:00:00 EST 1988
· J. Am. Acad. Dermatol.; (United States)
·
OSTI ID:6608246
Serum concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin and test results from selected residents of Seveso, Italy
Journal Article
·
Sun Mar 31 23:00:00 EST 1991
· Journal of Toxicology and Environmental Health; (USA)
·
OSTI ID:5760771
Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure to humans--Seveso, Italy
Journal Article
·
Thu Feb 09 23:00:00 EST 1989
· JAMA, Journal of the American Medical Association; (USA)
·
OSTI ID:5400332
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCIDENTS
AGE GROUPS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD CHEMISTRY
BODY
BODY FLUIDS
CHILDREN
DIGESTIVE SYSTEM
DIOXIN
ENVIRONMENTAL EXPOSURE
ENZYME ACTIVITY
ENZYMES
EUROPE
GLANDS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
ITALY
LIPIDS
LIVER
MATERIALS
MEDICAL SURVEILLANCE
METABOLISM
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
SURVEILLANCE
TRANSFERASES
URINE
WASTES
WESTERN EUROPE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCIDENTS
AGE GROUPS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD CHEMISTRY
BODY
BODY FLUIDS
CHILDREN
DIGESTIVE SYSTEM
DIOXIN
ENVIRONMENTAL EXPOSURE
ENZYME ACTIVITY
ENZYMES
EUROPE
GLANDS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
ITALY
LIPIDS
LIVER
MATERIALS
MEDICAL SURVEILLANCE
METABOLISM
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
SURVEILLANCE
TRANSFERASES
URINE
WASTES
WESTERN EUROPE