Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure to humans--Seveso, Italy

Journal Article · Fri Feb 10 04:00:00 EST 1989 · JAMA, Journal of the American Medical Association; (USA)

OSTI ID:5400332

On Saturday, July 10, 1976, an explosion occurred during the production of 2,4,5-trichlorophenol in a factory north of Milan, Italy. A cloud of toxic material was released and included 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The size of the contaminated area was estimated primarily by measuring TCDD in the soil; additional criteria included the presence of dead animals and detection of dermal lesions among persons in the area. In April 1988, a group of US and Italian scientists convened to further examine the Sevesco TCDD incident. Since more than 30,000 serum or plasma samples (volumes of 1-3 mL) had been collected from residents of the four zones from the end of July 1976 through 1985 and stored at {minus}30 C ({minus}22 F), the group agreed to assess whether methodology developed at CDC to measure TCDD in human serum could be used to measure TCDD in these low-volume samples. This metholodogy, a lipid-based measurement, highly correlated with paired measurements of TCDD in adipose tissue.

• OSTI ID: 5400332
• Journal Information: JAMA, Journal of the American Medical Association; (USA), Journal Name: JAMA, Journal of the American Medical Association; (USA) Vol. 261:6; ISSN 0098-7484; ISSN JAMAA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL TISSUES
AROMATICS
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
BODY
CHLORINATED AROMATIC HYDROCARBONS
CONNECTIVE TISSUE
DIOXIN
EUROPE
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HUMAN POPULATIONS
ITALY
LIPIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
POPULATIONS
TISSUES