Food proteins and gut mucosal barrier. IV. Effects of acute and chronic ethanol administration on handling and uptake of bovine serum albumin by rat small intestine

Journal Article · Sat Nov 01 00:00:00 EST 1986 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01296527· OSTI ID:6914189

Stern, M; Carter, E A; Walker, W A

The effects of ethanol exposure on small intestinal handling and uptake of radiolabeled bovine serum albumin were investigated using everted gut sacs. There was less breakdown of BSA after acute ethanol administration in vitro and after acute and chronic in vivo exposure. Thus, the vascular compartment of the small intestine was confronted with more complete and potentially more antigenic material after ethanol. Changes in BSA binding and uptake after acute exposure were shown to be reversible after 4-6 hr. In all groups, there was more BSA binding when the small intestine was exposed to ethanol. This difference was most pronounced after chronic exposure. In the same group, uptake of BSA was correlated with binding and significantly increased. Combined effects of ethanol on the gut mucosal barrier may account for changes in food antigen handling and uptake.

• Research Organization: Massachusetts General Hospital, Boston
• OSTI ID: 6914189
• Journal Information: Dig. Dis. Sci.; (United States), Vol. 11
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
INTESTINAL ABSORPTION
ETHANOL
BIOLOGICAL EFFECTS
ACUTE EXPOSURE
CHRONIC EXPOSURE
IN VITRO
IN VIVO
LABELLED COMPOUNDS
RATS
SMALL INTESTINE
TRACER TECHNIQUES
UPTAKE
ABSORPTION
ALCOHOLS
ANIMALS
BODY
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
HYDROXY COMPOUNDS
INTESTINES
ISOTOPE APPLICATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology