Influence of cadmium on the intestinal uptake and absorption of calcium in the rat

Journal Article · Wed Apr 01 04:00:00 EST 1981 · J. Nutr.; (United States)

OSTI ID:5172050

Chertok, R J ^[1]; Sasser, L B; Callaham, M F; Jarboe, G E

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1. Comparative Animal Research Lab., Oak Ridge, TN

To determine the effects of cadmium on the intestinal absorption of calcium, everted gut sacs from rats orally dosed with 0, 0.05, 0.5 or 5.0 mg Cd daily for 3 weeks were placed in media containing 4 x 10/sup -5/ M Ca. Tissue content of calcium after 1 hour incubation was approximately 1.5 times greater for the 5-mg Cd dose. Serosal fluid content of calcium was decreased by the 0.5- and 5-mg Cd/day doses. In other experiments, gut sacs were incubated in bathing media containing 4 x 10/sup -5/ Ca and Cd in concentrations of 10/sup -4/ to 10/sup -2/ M. Tissue and serosal fluid uptake of calcium decreased as Cd concentration increased. To determine the effects of cadmium on the accumulation of calcium against a concentration gradient, equimolar concentrations of Cd were placed in the mucosal and serosal fluids. Cadmium was added to the mucosal fluid. The accumulation of calcium was abolished by 1.5 x 10/sup -4/ M Cd while at 10/sup -6/ M Cd the accumulation was decreased to one-third the control value. The results indicate that acute or chronic exposure of the intestine to cadmium decreases the intestinal absorption of calcium.

• OSTI ID: 5172050
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 111:4; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
CADMIUM
CALCIUM 45
CALCIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPES
MAMMALS
METALS
NUCLEI
RADIOISOTOPES
RATS
RODENTS
UPTAKE
VERTEBRATES