Intestinal absorption of Cd in vitro
Journal Article
·
· Environ. Res.; (United States)
Everted gut sacs from the rat were utilized to characterize the movement of Cd across the intestinal tract. Total uptake of Cd (tissue content plus serosal fluid content) after incubation for 30 min as a function of the Cd concentration in mucosal fluid (range 5 ..mu..M to 3.4 mM) exhibited first-order kinetics. However, tissue Cd concentrations approached a steady state (1-5 ..mu..M Cd/g tissue) within 30-min incubation with mucosal concentrations greater than 1.2 x 10/sup -4/ M. Serosal fluid demonstrated an increased rate of accumulation of Cd at the higher mucosal fluid concentrations. This increased rate preceded the attainment of a steady state in tissue Cd by approximately 10 min. These results are consistent with the hypothesis that Cd diffuses into the intestinal tissue where part is bound and the remainder passes into the serosal fluid. As the tissue concentration of Cd approaches a steady state, increasing amounts of Cd move into the serosal fluid.
- Research Organization:
- Comparative Animal Research Lab., Oak Ridge, TN
- OSTI ID:
- 5456746
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 20:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CADMIUM
DATA
DATA FORMS
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
IN VITRO
INFORMATION
INTESTINAL ABSORPTION
INTESTINES
ISOLATED VALUES
KINETICS
MAMMALS
MATERIALS
METABOLISM
METALS
NUMERICAL DATA
ORGANS
QUANTITY RATIO
RATS
REACTION KINETICS
RODENTS
SMALL INTESTINE
TIME DEPENDENCE
TISSUE CULTURES
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CADMIUM
DATA
DATA FORMS
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
IN VITRO
INFORMATION
INTESTINAL ABSORPTION
INTESTINES
ISOLATED VALUES
KINETICS
MAMMALS
MATERIALS
METABOLISM
METALS
NUMERICAL DATA
ORGANS
QUANTITY RATIO
RATS
REACTION KINETICS
RODENTS
SMALL INTESTINE
TIME DEPENDENCE
TISSUE CULTURES
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES