Human T-cell lymphotropic virus type III infection of the central nervous system: a preliminary in situ analysis
Patients with acquired immunodeficiency syndrome (AIDS) are subject to a spectrum of central nervous system (CNS) disorders. Recent evidence implicates the human T-cell lymphotropic virus type III (HTLV-III) in the pathogenesis of some of these illnesses, although the cells infected by the virus have yet to be identified. Using in situ hybridization, the authors examined brain tissue from two patients with AIDS encephalopathy for the presence of HTLV-III RNA. In both cases, viral RNA was detected and concentrated in, though not limited to, the white matter. The CNS cells most frequently infected included macrophages, pleomorphic microglia, and multinucleated giant cells. Less frequently, cells morphologically consistent with astrocytes, oligodendroglia, and rarely neurons were also infected. The findings strengthen the association of HTLV-III with the pathogenesis of AIDS encephalopathy. In situ hybridization can be applied to routinely prepared biopsy tissue in the diagnosis of HTLV-III infection of the CNS.
- Research Organization:
- Univ. of Rochester, NY
- OSTI ID:
- 6906724
- Journal Information:
- JAMA, J. Am. Med. Assoc.; (United States), Vol. 256:17
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AIDS
PATHOGENESIS
AIDS VIRUS
DIAGNOSIS
RNA
RADIOASSAY
CENTRAL NERVOUS SYSTEM
PATIENTS
SULFUR 35
TRITIUM COMPOUNDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
HEMIC DISEASES
INFECTIOUS DISEASES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MICROORGANISMS
NERVOUS SYSTEM
NUCLEI
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
RADIOISOTOPES
SULFUR ISOTOPES
VIRAL DISEASES
VIRUSES
550601* - Medicine- Unsealed Radionuclides in Diagnostics