Human immunodeficiency virus type 1 expression in the central nervous system correlates directly with extent of disease

Journal Article · Tue May 01 04:00:00 EDT 1990 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.87.10.3997· OSTI ID:5393833

Weiser, B; La Neve, D; Eilbott, D J; Burger, H; Seidman, R ^[1]; Peress, N ^[2]

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1. State Univ. of New York, Stony Brook (USA)
2. State Univ. of New York, Stony Brook (USA) Veterans Administration Medical Center, Northport, NY (USA)

To investigate human immunodeficiency virus type 1 (HIV-1) pathogenesis in infected individuals and examine the correlation of HIV-1 expression with extent of clinical and pathologic disease, the authors studied spinal cords from acquired immunodeficiency syndrome patients with a wide range of spinal cord pathology. By performing in situ hybridization with HIV-1-specific riboprobes, they detected HIV-1 RNA in all 10 cords from acquired immunodeficiency syndrome patients with a common, characteristic pathologic entity called vacuolar myelopathy but not in 10 control cords from HIV-1-infected and uninfected patients. In the cords from individuals with vacuolar myelopathy, the level of HIV-1 RNA expression correlated directly with extent of spinal cord pathology and clinical findings. These data support a role for HIV-1 int he pathogenesis of tissue damage and related clinical disease in infected individuals.

• OSTI ID: 5393833
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 87:10; ISSN PNASA; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AIDS
AIDS VIRUS
BIOCHEMISTRY
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CYTOCHEMISTRY
DISEASES
DNA HYBRIDIZATION
GENE REGULATION
HISTOLOGY
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
MICROORGANISMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
PARASITES
PATHOGENESIS
PATIENTS
SPINAL CORD
VIRAL DISEASES
VIRUSES