Fusion as a mediator of cytolysis in mixtures of uninfected CD4/sup +/ lymphocytes and cells infected by human immunodeficiency virus
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
The authors describe an unusual type of cytopathology in which uninfected CD4/sup +/ (helper/inducer) cells (cells expressing the human leukocyte antigen CD4) interact with cells persistently infected with the human immunodeficiency virus (HIV). Prior antigenic stimulation was not required, since CD4/sup +/ cells taken either from healthy persons without anti-HIV antibodies or from individuals with anti-HIV antibodies were capable in inducing cytolysis. Neither CD8/sup +/ (suppressor/cytotoxic) nor CD16/sup +/ (natural killer) cells mediated the reaction. Light microscopic and autoradiographic studies revealed that, prior to cytolysis, multinucleated giant cells were formed from fusions between HIV-infected cells and large numbers of uninfected CD4/sup +/ lymphocytes. These data may explain the paradox that exists in vivo in which a dramatic depletion of CD4/sup +/ lymphocytes occurs in the presence of a small number of HIV-infected CD4/sup +/ cells. These new insights into the pathogenesis of acquired immunodeficiency syndrome (AIDS) may lead to future therapeutic strategies.
- Research Organization:
- Baylor College of Medicine, Houston, TX
- OSTI ID:
- 6124324
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:5; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AIDS
ANIMAL CELLS
ANTIGENS
AUTORADIOGRAPHY
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
LYSIS
MATERIALS
MICROORGANISMS
MORPHOLOGICAL CHANGES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PATHOGENESIS
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
SOMATIC CELLS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VIRAL DISEASES
VIRUSES
62 RADIOLOGY AND NUCLEAR MEDICINE
AIDS
ANIMAL CELLS
ANTIGENS
AUTORADIOGRAPHY
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
LYSIS
MATERIALS
MICROORGANISMS
MORPHOLOGICAL CHANGES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PATHOGENESIS
PYRIMIDINES
RADIOISOTOPES
RIBOSIDES
SOMATIC CELLS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VIRAL DISEASES
VIRUSES