Phase-dependent response of the lung to NO sub 2 irritant insult
Journal Article
·
· Journal of Environmental Pathology, Toxicology and Oncology; (USA)
OSTI ID:6905374
- Tulane Univ. School of Medicine, New Orleans, LA (USA)
The biochemical and histopathological response of the lung following acute and repeated (subacute) exposure to nitrogen oxide (NO{sub 2}) was examined. Activities of lactate dehydrogenase, beta-glucuronidase, choline kinase, and protease inhibitor were measured in murine pulmonary tissue immediately and two days following exposure. Nonenzymatic parameters, pulmonary protein content, and wet lung weight were also monitored. Immediately following acute exposure to NO{sub 2}, only the nonenzymatic parameters were elevated. By two days following acute exposure, following subacute exposure; however, the nonenzymatic parameters were attenuated with respect to the enzymatic activities. The lung exhibits a dynamic response following damage by oxidants such as NO{sub 2}. This response is divided into three distinct phases (exudative, proliferative, and tolerant), which can be characterized both biochemically and histopathologically.
- OSTI ID:
- 6905374
- Journal Information:
- Journal of Environmental Pathology, Toxicology and Oncology; (USA), Journal Name: Journal of Environmental Pathology, Toxicology and Oncology; (USA) Vol. 9:4; ISSN 0731-8898; ISSN JEPOE
- Country of Publication:
- United States
- Language:
- English
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560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
BODY
CHALCOGENIDES
ENZYME ACTIVITY
ENZYME INHIBITORS
ENZYMES
GLUCURONIDASE
GLYCOSYL HYDROLASES
HEMIACETAL DEHYDROGENASES
HYDROLASES
INHALATION
INTAKE
LACTATE DEHYDROGENASE
LUNGS
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PEPTIDE HYDROLASES
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PROTEINS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
TRANSFERASES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
BODY
CHALCOGENIDES
ENZYME ACTIVITY
ENZYME INHIBITORS
ENZYMES
GLUCURONIDASE
GLYCOSYL HYDROLASES
HEMIACETAL DEHYDROGENASES
HYDROLASES
INHALATION
INTAKE
LACTATE DEHYDROGENASE
LUNGS
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PEPTIDE HYDROLASES
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PROTEINS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
TRANSFERASES
VERTEBRATES