Bioavailability in rats of bound /sup 14/C residues from corn plants treated with (/sup 14/C)atrazine

Journal Article · · J. Agric. Food Chem.; (United States)

OSTI ID:6898353

Khan, S U; Kacew, S; Molnar, S J

Corn plants grown to the silage stage were treated with /sup 14/C ring-labeled and unlabeled atrazine. The aerial portion of the plants was exhaustively extracted with solvents and the extracted material containing bound /sup 14/C residues was fed to rats. For comparison extracted material from control plants fortified with (/sup 14/C)atrazine was also fed to rats. After 4 days, 88% of the dose was excreted in the feces and 10% in the urine from rats fed plant material containing bound /sup 14/C residues. In contrast, only 32% of the dose was eliminated in the feces while 60% was voided via the urine when the corn material fortified with (/sup 14/C)atrazine was fed to rats. Most of the /sup 14/C residues in feces from rats fed bound diet remained nonextractable and their amounts and nature were similar to those in the corn material. Atrazine added to the corn material before feeding was metabolized effectively when consumed by rats. The data demonstrated that bound residues in corn plant treated with atrazine have a low degree of bioavailability in rats.

• Research Organization: Agriculture Canada, Ottawa
• OSTI ID: 6898353
• Journal Information: J. Agric. Food Chem.; (United States), Journal Name: J. Agric. Food Chem.; (United States) Vol. 33:4; ISSN JAFCA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL AVAILABILITY
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CEREALS
FECES
GRASS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAIZE
MAMMALS
MATERIALS
METABOLISM
PESTICIDES
PLANTS
RATS
RODENTS
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES