Bioavailability in rats of bound residues from radishes treated with either radiolabeled dieldrin or carbofuran
The bioavailability of bound residues from radishes treated with (/sup 14/C)dieldrin and (/sup 14/C)carbofuran was investigated by feeding the rats /sup 14/C material obtained after exhaustive solvent extraction. For comparison, nonextracted radishes were also fed to rats. The /sup 14/C residues were predominantly excreted in feces. Urinary excretion of /sup 14/C from rats fed nonextracted material was relatively greater than from those fed extracted radishes. The excreted material from rats fed dieldrin-treated radishes contained mainly parent compounds as residue. However, carbofuran and two of its metabolites, 3-hydroxycarbofuran and 3-ketocarbofuran, were present in feces and urine samples of rats fed carbofuran-treated radishes. These data demonstrated that bound residues in radishes treated with dieldrin and carbofuran have a low degree of bioavailability in rats. The results also show that bound residues in dieldrin-treated radishes would be more bioavailable than in the carbofuran-treated samples.
- Research Organization:
- Agriculture Canada, Ottawa, Ontario
- OSTI ID:
- 6641560
- Journal Information:
- J. Agric. Food Chem.; (United States), Journal Name: J. Agric. Food Chem.; (United States) Vol. 35:1; ISSN JAFCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL AVAILABILITY
CARBON 14 COMPOUNDS
DIELDRIN
EXTRACTION
FOOD
FURANS
HETEROCYCLIC COMPOUNDS
INSECTICIDES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
METABOLITES
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PESTICIDES
PLANTS
RADISHES
RATS
RESIDUES
RODENTS
SEPARATION PROCESSES
SOLVENT EXTRACTION
TRACER TECHNIQUES
VEGETABLES
VERTEBRATES