Bound sup 14 C residues in stored wheat treated with ( sup 14 C)deltamethrin and their bioavailability in rats

Journal Article · Sat Mar 31 23:00:00 EST 1990 · Journal of Agricultural and Food Chemistry; (USA)

DOI:https://doi.org/10.1021/jf00094a037· OSTI ID:6068477

Khan, S U; Kacew, S ^[1]; Akhtar, M H ^[2]

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1. Agriculture Canada, Ottawa, Ontario (Canada)
2. Univ. of Ottawa, Ontario (Canada)

Wheat grains treated with radiolabeled deltamethrin ((S)-{alpha}-cyano-3-phenoxybenzyl (1R,3R)-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate) and stored in the laboratory for 168 days formed bound (nonextractable) {sup 14}C residues. The amount of bound {sup 14}C residues formed was about 11% of the total {sup 14}C in stored grain. Br{sub 2}CA (3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid) and 3-PBacid (3-phenoxybenzoic acid) were present in the form of bound {sup 14}C residues in addition to some radiolabeled product of unknown composition. The stored wheat containing bound {sup 14}C was fed to rats. The {sup 14}C residues were excreted in urine and feces in nearly equal proportion. The {sup 14}C residues identified in urine were Br{sub 2}CA, 3-PBacid, and conjugated compounds of 4{prime}-OH-3-PBacid (3-(4-hydroxyphenoxy)benzoic acid). Most of the {sup 14}C residues excreted in feces were extractable with methanol. Trace amounts of {sup 14}C residues were also present in lungs, kidney, and liver. The results suggest that bound residues in stored wheat treated with deltamethrin when fed to rats are highly bioavailable.

• OSTI ID: 6068477
• Journal Information: Journal of Agricultural and Food Chemistry; (USA), Journal Name: Journal of Agricultural and Food Chemistry; (USA) Vol. 38:4; ISSN JAFCA; ISSN 0021-8561
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
553003* -- Agriculture & Food Technology-- Pest & Disease Control-- (1987-)
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGRICULTURE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBON 14
CARBON ISOTOPES
CEREALS
EVEN-EVEN NUCLEI
FOOD INDUSTRY
GRAMINEAE
INDUSTRY
INSECTICIDES
ISOTOPES
LIGHT NUCLEI
LILIOPSIDA
MAGNOLIOPHYTA
MAMMALS
NUCLEI
PESTICIDES
PLANTS
RADIOISOTOPES
RATS
RODENTS
TISSUES
TOXICITY
VERTEBRATES
WHEAT
YEARS LIVING RADIOISOTOPES