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Norepinephrine release in arteries of spontaneously hypertensive rats

Journal Article · · Clin. Exp. Hypertens.; (United States)
; ; ;
The role of the sympathetic nervous system in arterial hypertension cannot be properly evaluated until it is known about the activity in the vessels themselves. In this study researchers investigated the effect of transmural stimulation on the tail artery - labelled in vitro with /sup 3/H-norepinephrine - of 7-9 week old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKR). Electrical stimulation using two frequencies (2 and 10 Hz) resulted in significantly more /sup 3/H overflow in vessels from SHR than from WKR. With 10 Hz stimulation the fractional release was also greater. Column chromatographic analysis of /sup 3/H overflow revealed that transmural stimulation in arteries of SHR enhanced mainly the release of norepinephrine and not of its metabolites. Significantly, an increased release of /sup 3/H-norepinephrine on stimulation was observed in SHR before the full development of hypertension suggesting that it might be a cause rather than a consequence of high blood pressure.
Research Organization:
Department of Pharmacology, University of Toronto, Ontario, Canada
OSTI ID:
6879196
Journal Information:
Clin. Exp. Hypertens.; (United States), Journal Name: Clin. Exp. Hypertens.; (United States) Vol. 4:3; ISSN CEHYD
Country of Publication:
United States
Language:
English

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Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMALS
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
HORMONES
HYPERTENSION
IN VITRO
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANS
PATHOLOGY
RATS
RODENTS
STEROID HORMONES
STIMULATION
SYMPATHOMIMETICS
SYMPTOMS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VASCULAR DISEASES
VERTEBRATES