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Effect of sodium depletion on the release of /sup 3/Hnorepinephrine from central and peripheral tissue of Wistar-Kyoto and spontaneously hypertensive rats

Journal Article · · J. Cardiovasc. Pharmacol.; (United States)
; ; ;

To study the relationship between sodium intake, the sympathetic nervous system, and hypertension, a study was made of the effects of a 7-9 day dietary restriction of sodium in three different ages of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). Field-stimulated (/sup 3/H)norepinephrine ( (/sup 3/H)NE) release was measured in portal vein, anterior hypothalamus, and the A2 region of the nucleus tractus solitarius (NTS) of 5- to 6-, 10- to 11-, and 28- to 30- week-old SHR and age-matched WKY. A low-sodium diet (0.05% Na+, control 0.5% Na+) significantly lowered stimulated (/sup 3/H)NE release from portal vein and anterior hypothalamus in SHR and WKY at all three ages. However, release from the A2 region was not altered by sodium restriction. The results of the present study suggest that lowered dietary sodium can selectively alter norepinephrine release in both the peripheral and central sympathetic nervous system of SHR and WKY. The results also suggest that the SHR at 5-6 weeks are more sensitive to altered dietary sodium than are age-matched WKY.

Research Organization:
St. Louis Univ. School of Medicine, MO
OSTI ID:
5518115
Journal Information:
J. Cardiovasc. Pharmacol.; (United States), Journal Name: J. Cardiovasc. Pharmacol.; (United States) Vol. 7:1; ISSN JCPCD
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALKALI METALS
ANIMALS
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DIET
DISEASES
DRUGS
ELEMENTS
HORMONES
HYPERTENSION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
METALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
PHYSIOLOGY
RATS
REACTION KINETICS
RODENTS
SODIUM
STEROID HORMONES
SYMPATHOMIMETICS
SYMPTOMS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VASCULAR DISEASES
VERTEBRATES