Increased norepinephrine release during sympathetic nerve stimulation and its inhibition by adenosine in the isolated perfused kidney of spontaneously hypertensive rats

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Clin. Exp. Hypertens.; (United States)

DOI:https://doi.org/10.3109/10641968309048809· OSTI ID:5776748

Ekas, Jr, R D; Steenberg, M L; Lokhandwala, M F

The present study was performed to measure norepinephrine release during sympathetic nerve stimulation and determine the inhibitory action of adenosine on stimulus-induced release of norepinephrine in the isolated perfused kidney of WKY and SHR. Norepinephrine release during periarterial nerve stimulation was measured as total /sup 3/H-overflow since greater than 75% of total /sup 3/H-overflow was /sup 3/H-norepinephrine in both the WKY and SHR. A significantly greater increase in /sup 3/H-norepinephrine overflow was observed during periarterial nerve stimulation in SHR in comparison with WKY. Adenosine (0.3, 1.0, 3.0 and 10.0 micrograms/ml) produced dose-dependent inhibition of /sup 3/H-norepinephrine overflow elicited by periarterial nerve stimulation. However, the effect of adenosine on transmitter release was more pronounced in the SHR in that the threshold dose required to cause inhibition of stimulus-induced release of /sup 3/H-norepinephrine was smaller in the SHR. These results demonstrate that while norepinephrine release during sympathetic nerve stimulation is greater in the SHR, this finding can not be explained on the basis of a decrease in the presynaptic inhibitory action of adenosine. Therefore, the mechanism responsible for the increased release of norepinephrine in the SHR remains to be determined.

• Research Organization: Department of Pharmacology, College of Pharmacy, University of Houston, TX
• OSTI ID: 5776748
• Journal Information: Clin. Exp. Hypertens.; (United States), Journal Name: Clin. Exp. Hypertens.; (United States) Vol. 5:1; ISSN CEHYD
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADENOSINE
ADRENAL HORMONES
ANIMALS
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DISEASES
DRUGS
HORMONES
HYPERTENSION
INHIBITION
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
RATS
RIBOSIDES
RODENTS
SECRETION
STEROID HORMONES
STIMULATION
SYMPATHOMIMETICS
SYMPTOMS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VASCULAR DISEASES
VERTEBRATES