Increased activity of digoxin-like substance in low-renin hypertension in acromegaly

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Clinical and Experimental Hypertension, Part A: Theory and Practice; (USA)

DOI:https://doi.org/10.3109/10641969009073483· OSTI ID:6870291

Soszynski, P; Slowinska-Srzednicka, J; Zgliczynski, S ^[1]

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1. Medical Center for Postgraduate Education, Warsaw (Poland)

Arterial hypertension is common in acromegaly, but the pathogenesis of this complication remains unknown. To determine the role of an endogenous Na,K pump inhibitor/digoxin-like substance (DLS) in the pathogenesis of hypertension in acromegaly 76 subjects: 28 with acromegaly, 20 with essential hypertension and 28 healthy controls were studied. Serum DLS was measured with the use of radioimmunoassay and bioassay by the inhibition of digoxin-sensitive erythrocyte 86-Rb uptake. In acromegaly, the activity of DLS was significantly increased and plasma renin activity decreased in the hypertensive group, as compared with that of the normotensive group and controls. Moreover, DLS was elevated in the low-renin group of essential hypertension, as compared with that of the normal/high-renin group or controls. The activity of DLS correlated positively with mean arterial pressure and negatively with plasma renin activity, but not with growth hormone levels. In conclusion, an endogenous sodium pump inhibitor/digoxin-like substance may play a role in the pathogenesis of low-renin hypertension in acromegaly.

• OSTI ID: 6870291
• Journal Information: Clinical and Experimental Hypertension, Part A: Theory and Practice; (USA), Journal Name: Clinical and Experimental Hypertension, Part A: Theory and Practice; (USA) Vol. 12:4; ISSN CEHAD; ISSN 0730-0077
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOASSAY
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PRESSURE
BODY FLUIDS
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGITALIS GLYCOSIDES
DIGOXIN
DISEASES
DRUGS
ENZYMES
ERYTHROCYTES
GLYCOSIDES
HORMONES
HYDROLASES
HYPERTENSION
IMMUNOASSAY
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MAN
MATERIALS
MINUTES LIVING RADIOISOTOPES
NONSPECIFIC PEPTIDASES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PATHOGENESIS
PEPTIDE HORMONES
PEPTIDE HYDROLASES
PITUITARY HORMONES
PRIMATES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPES
REACTION KINETICS
RENIN
RUBIDIUM 86
RUBIDIUM ISOTOPES
SKELETAL DISEASES
STH
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES