An immunochemical approach to the study of DNA damage and repair: Technical progress report for period August 1, 1987--July 31, 1988
Technical Report
·
OSTI ID:6869127
The overall objective for this project is to develop immunochemical methods to quantitate unique DNA base damages in x-irradiated DNA. Our approach has been to chemically synthesize modified nucleotides, conjugate them to protein carriers, and use the conjugates as immunogens in rabbits or to prepare monoclonal antibodies. We are studying damages that have been shown to be stable radiolysis products found in x-irradiated DNA and thus products that have potential biological consequence. Several thymine ring saturation or fragmentation products have been chosen as models for pyrimidine radiolysis products. For the present project period, we planned to use the characterized antibodies to quantitate DNA damage x-irradiated in vitro, to immunochemically characterize the antibody to dihydrothymine, and to develop new mono and polyclonal antibodies to model modified DNA bases. 41 refs.
- Research Organization:
- Vermont Univ., Burlington (USA)
- DOE Contract Number:
- FG02-88ER60742
- OSTI ID:
- 6869127
- Report Number(s):
- DOE/ER/60742-1; ON: DE89004123
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ANTIBODIES
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHEMICAL ANALYSIS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
CHROMOSOMAL ABERRATIONS
CHROMOSOME BREAKAGE
DECOMPOSITION
DNA REPAIR
DOCUMENT TYPES
DRUGS
EQUIPMENT
GLYCOLS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNOASSAY
LABELLED COMPOUNDS
MONOCLONAL ANTIBODIES
MUTATIONS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRODUCTION
PROGRESS REPORT
PYRIMIDINES
QUANTITATIVE CHEMICAL ANALYSIS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATION SOURCES
RADIOLYSIS
RADIOPHARMACEUTICALS
RECOVERY
REPAIR
THYMINE
URACILS
X-RAY EQUIPMENT
X-RAY SOURCES
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ANTIBODIES
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHEMICAL ANALYSIS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
CHROMOSOMAL ABERRATIONS
CHROMOSOME BREAKAGE
DECOMPOSITION
DNA REPAIR
DOCUMENT TYPES
DRUGS
EQUIPMENT
GLYCOLS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNOASSAY
LABELLED COMPOUNDS
MONOCLONAL ANTIBODIES
MUTATIONS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRODUCTION
PROGRESS REPORT
PYRIMIDINES
QUANTITATIVE CHEMICAL ANALYSIS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATION SOURCES
RADIOLYSIS
RADIOPHARMACEUTICALS
RECOVERY
REPAIR
THYMINE
URACILS
X-RAY EQUIPMENT
X-RAY SOURCES