Development of advanced methods for early detection of lung cancer in the uranium miner/worker population

Technical Report · Sat Jan 01 04:00:00 EST 1983

OSTI ID:6868694

Profio, A E; Balchum, O J; Saccomanno, G; Huth, G C

Fluorescence bronchoscopy with a violet laser and image intensifier has been developed for imaging the red fluorescence of a tumor-specific agent, hematoporphyrin derivative, that has been injected before the examination. The instrument was developed to localize carcinoma in situ and early, small bronchogenic tumors diagnosed by sputum cytology but invisible on chest x-ray and conventional bronchoscopy, in underground uranium miners and others at risk for lung cancer. In addition to the imaging devices, a video system including a processor and electronics for digital background image subtraction has been developed to enhance contrast. A ratio fluorometer and a rapid-scan spectrum analyzer have been designed for quantitative measurements of fluorescence intensity and dependence on dosage and time after injection of the fluorescent agent. Clinical trials demonstrate detection of carcinoma in situ, and the true positive rate should be improved by the new instrumentation and optimization of time delay and dosage. 14 references, 6 figures.

• Research Organization: California Univ., Los Angeles (USA)
• DOE Contract Number: AM03-76SF00113
• OSTI ID: 6868694
• Report Number(s): DOE/SF/00113-T5; ON: DE84015619
• Country of Publication: United States
• Language: English

Related Subjects

054000 -- Nuclear Fuels-- Health & Safety
11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS
550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOASSAY
BODY
BRONCHI
DESIGN
DIAGNOSTIC TECHNIQUES
DISEASES
FLUORESCENCE
IMAGE INTENSIFIERS
IMAGE PROCESSING
LASERS
LUMINESCENCE
LUNGS
MINERS
MINES
NEOPLASMS
ORGANS
PERSONNEL
PROCESSING
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
UNDERGROUND FACILITIES
URANIUM MINES