Laser fluorescence bronchoscope for localization of occult lung tumors

Journal Article · Thu Nov 01 04:00:00 EST 1979 · Med. Phys.; (United States)

OSTI ID:5868305

Profio, A E; Doiron, D R; King, E G

A system for imaging occult bronchogenic carcinoma by the fluorescence of previously-injected, tumor-specific compound hematoporphyrin-derivative has been assembled and successfully used to locate a tumor l mm thick. The violet excitation source is a krypton ion laser coupled to fused quartz fiber light conductor. An electrostatic image intensifier attached to a standard flexible fiberoptic bronchoscope provides a bright image even at relatively low irradiance. A red secondary filter rejects most reflected background and autofluorescence. Sensitivity and contrast capability of the system should permit detection of a tumor less than 0.1 mm thick.

• Research Organization: Medical Imaging Science Group, University of Southern California School of Medicine
• OSTI ID: 5868305
• Journal Information: Med. Phys.; (United States), Journal Name: Med. Phys.; (United States) Vol. 6:6; ISSN MPHYA
• Country of Publication: United States
• Language: English

Related Subjects

560100* -- Biomedical Sciences
Applied Studies-- Radiation Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOMEDICAL RADIOGRAPHY
BODY
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTROMAGNETIC RADIATION
FLUORESCENCE
FLUOROSCOPY
IMAGE INTENSIFIERS
IMAGES
LASER RADIATION
LUMINESCENCE
LUNGS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATIONS
RADIOLOGY
RESPIRATORY SYSTEM
SENSITIVITY