Early lung cancer: detection, treatment outcome

Technical Report · Sun Jan 01 04:00:00 EST 1984

OSTI ID:6735001

Balchum, O J; Huth, G C; Saccomanno, G

The performance of a room temperature mercuric iodide x-ray detector was investigated as a function of detector bias, amplifier time constant, and detector temperature. A Mn K/sub ..cap alpha../ line of 200 eV FWHM was obtained by using low noise electronics developed for Si(Li) detectors, including a cooled input FET. Measurements of the detector's resolution at various x-ray energies result in a Fano factor of 0.20. Fluorescence bronchoscopy with a violet laser and image intensifier has been developed for imaging the red fluorescence of a tumor-specific agent, hematoporphyrin derivative, that has been injected before the examination. The instrument was developed to localize carcinoma in situ and early, small bronchogenic tumors diagnosed by sputum cytology but invisible on chest x-ray and conventional bronchoscopy, in underground uranium miners and others at risk for lung cancer. In addition to the imaging devices, a video system including a processor and electronics for digital background image subtraction has been developed to enhance contrast. A ratio fluorometer and a rapid-scan spectrum analyzer have been designed for quantitative measurements of fluorescence intensity and dependence on dosage and time after injection of the fluorescent agent. Clinical trials demonstrate detection of carcinoma in situ, and the true positive rate should be improved by the new instrumentation and optimization of time delay and dosage.

• Research Organization: Saint Mary's Hospital, Grand Junction, CO (USA)
• DOE Contract Number: AM03-76SF00113
• OSTI ID: 6735001
• Report Number(s): DOE/SF/00113-T2; ON: DE84013932
• Country of Publication: United States
• Language: English

Related Subjects

440101* -- Radiation Instrumentation-- General Detectors or Monitors & Radiometric Instruments
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMPLIFIERS
BODY
DIAGNOSIS
DISEASES
ELECTRONIC EQUIPMENT
ELECTRONIC STRUCTURE
ENERGY RESOLUTION
EQUIPMENT
FIELD EFFECT TRANSISTORS
HGI2 SEMICONDUCTOR DETECTORS
K SHELL
LUNGS
MEASURING INSTRUMENTS
MINERS
NEOPLASMS
ORGANS
PERSONNEL
PREAMPLIFIERS
RADIATION DETECTORS
RESOLUTION
RESPIRATORY SYSTEM
SEMICONDUCTOR DETECTORS
SEMICONDUCTOR DEVICES
TRANSISTORS