Effect of estrogen/gestagen and 24R,25-dihydroxyvitamin D3 therapy on bone formation in postmenopausal women
Journal Article
·
· J. Bone Miner. Res.; (United States)
The effect of two different estrogen/gestagen regimens and 24R,25-(OH)2-cholecalciferol on bone formation was studied in a randomized trial with 144 healthy postmenopausal women. Urinary excretion (UE) of /sup 99m/technetium-diphosphonate and serum alkaline phosphatase (AP) was determined before and then once a year for 2 years of treatment. Both estimates of bone formation showed highly significant decreases (p less than .001) to normal premenopausal levels in women receiving unopposed 17 beta-estradiol or in a sequential combination with progestagen, whereas unchanged high values were found in the groups receiving 24R,25-(OH)2D3 and placebo. The data show that bone turnover increases in early postmenopausal women concomitantly with the loss of bone mass, and that hormonal substitutional therapy normalizes the total skeletal turnover as well as preventing bone loss.
- Research Organization:
- Univ. of Copenhagen, Glostrup Hospital (Denmark)
- OSTI ID:
- 6866155
- Journal Information:
- J. Bone Miner. Res.; (United States), Journal Name: J. Bone Miner. Res.; (United States) Vol. 1:6; ISSN JBMRE
- Country of Publication:
- United States
- Language:
- English
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·
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Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE PHOSPHATASE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
CHEMOTHERAPY
DISEASES
ENZYMES
ESTERASES
ESTROGENS
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROLASES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MENOPAUSE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OSTEOPOROSIS
PHOSPHATASES
RADIOISOTOPES
RECOVERY
SKELETAL DISEASES
SKELETON
STEROID HORMONES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TRACER TECHNIQUES
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES
59 BASIC BIOLOGICAL SCIENCES
ALKALINE PHOSPHATASE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
CHEMOTHERAPY
DISEASES
ENZYMES
ESTERASES
ESTROGENS
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROLASES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MENOPAUSE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OSTEOPOROSIS
PHOSPHATASES
RADIOISOTOPES
RECOVERY
SKELETAL DISEASES
SKELETON
STEROID HORMONES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TRACER TECHNIQUES
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES