Hydroxyproline peptides and bone mass in postmenopausal and osteoporotic women
Total and nondialyzable hydroxyproline excretion was measured in 59 postmenopausal women and 68 women with spinal osteoporosis. Hydroxyproline excretion was similar in both groups of women and the hypothesis that hydroxyproline excretion is normally distributed could not be rejected for either group. No relationship was found between hydroxyproline excretion (total and percentage of nondialyzable) and body weight, height, body surface area, or total body potassium; there was also no relationship found with total body calcium or bone mineral content of the radius, or these latter values normalized for age, sex, and body size. There was no difference in hydroxyproline excretion in osteoporotic women who took supplemental calcium as compared to those that did not. These data fail to provide any evidence that bone turnover in osteoporotic women differs from that in younger postmenopausal women, or that osteoporosis arises from a subpopulation of women with rapid bone loss.
- Research Organization:
- Brookhaven National Lab., Upton, NY
- OSTI ID:
- 6688125
- Journal Information:
- J. Clin. Endocrinol. Metab.; (United States), Journal Name: J. Clin. Endocrinol. Metab.; (United States) Vol. 47:2; ISSN JCEMA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ACTIVATION ANALYSIS
ALKALI METALS
ALKALINE EARTH METALS
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BARYON REACTIONS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CALCIUM
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
CLEARANCE
CORRELATIONS
COUNTING TECHNIQUES
DISEASES
ELEMENTS
EXCRETION
FEMALES
HADRON REACTIONS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
HYDROXYPROLINE
MAMMALS
MAN
MENOPAUSE
METALS
NEUTRON REACTIONS
NUCLEAR REACTIONS
NUCLEON REACTIONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OSTEOPOROSIS
POTASSIUM
PRIMATES
PYRROLES
PYRROLIDINES
SKELETAL DISEASES
URINE
VERTEBRATES
WASTES
WHOLE-BODY COUNTING
WOMEN