Rate of bone loss in postmenopausal and osteoporotic women

Journal Article · Mon Feb 01 04:00:00 EST 1982 · Am. J. Physiol.; (United States)

OSTI ID:5478246

Aloia, J F ^[1]; Ross, P; Vaswani, A; Zanzi, I; Cohn, S H

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1. Brookhaven National Lab., Upton, NY

Regional and total bone mass were determined in three groups of women by photon absorptiometry of the distal radius (bone mineral content (BMC)) and total neutron activation analysis (total body calcium (TBCa)), respectively. There were three groups of patients: group A, osteoporotic women treated with a variety of pharmacologic agents; group B, osteoporotic women (controls) taking only calcium supplements; and group C, normal postmenopausal women. The mean TBCa and BMC were considerably higher in the postmenopausal women than in the osteoporotic women. The rate of change of bone mass in group C was -0.45%/yr and -0.9%/yr for the total skeleton and radius, respectively. Group B had no significant rate of loss, whereas group A demonstrated a significant increase in TBCa of 0.75%/yr with no change in the BMC of the radius. There were no significant between-subject correlations for the slopes (rates of change) of the two bone mineral measurements.

• DOE Contract Number: EY-76-C-02-0016
• OSTI ID: 5478246
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 242:2; ISSN AJPHA
• Country of Publication: United States
• Language: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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62 RADIOLOGY AND NUCLEAR MEDICINE
ACTIVATION ANALYSIS
ALKALINE EARTH METALS
ANIMALS
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SKELETAL DISEASES
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