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Rate of bone loss in postmenopausal and osteoporotic women

Journal Article · · Am. J. Physiol.; (United States)
OSTI ID:5478246
 [1]; ; ; ;
  1. Brookhaven National Lab., Upton, NY
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Regional and total bone mass were determined in three groups of women by photon absorptiometry of the distal radius (bone mineral content (BMC)) and total neutron activation analysis (total body calcium (TBCa)), respectively. There were three groups of patients: group A, osteoporotic women treated with a variety of pharmacologic agents; group B, osteoporotic women (controls) taking only calcium supplements; and group C, normal postmenopausal women. The mean TBCa and BMC were considerably higher in the postmenopausal women than in the osteoporotic women. The rate of change of bone mass in group C was -0.45%/yr and -0.9%/yr for the total skeleton and radius, respectively. Group B had no significant rate of loss, whereas group A demonstrated a significant increase in TBCa of 0.75%/yr with no change in the BMC of the radius. There were no significant between-subject correlations for the slopes (rates of change) of the two bone mineral measurements.

DOE Contract Number:
EY-76-C-02-0016
OSTI ID:
5478246
Journal Information:
Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 242:2; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400101 -- Activation
Nuclear Reaction
Radiometric & Radiochemical Procedures
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTIVATION ANALYSIS
ALKALINE EARTH METALS
ANIMALS
BARYON REACTIONS
BODY
CALCIUM
CHEMICAL ANALYSIS
DIAGNOSIS
DISEASES
DRUGS
ELEMENTARY PARTICLES
ELEMENTS
FEMALES
HADRON REACTIONS
MAMMALS
MAN
MASS
MASSLESS PARTICLES
MENOPAUSE
METALS
NEUTRON REACTIONS
NUCLEAR REACTIONS
NUCLEON REACTIONS
ORGANS
OSTEOPOROSIS
PATIENTS
PHOTONS
PRIMATES
QUANTITY RATIO
SKELETAL DISEASES
SKELETON
VERTEBRATES
WOMEN