Survival of parenchymal hepatocytes irradiated with 14. 3 MeV neutrons. [Rats]

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90392-4· OSTI ID:6864858

Jirtle, R L; DeLuca, P M; Hinshaw, W M; Gould, M N

The purpose of these experiments was to estimate the RBE of neutrons for parenchymal hepatocytes as a function of neutron dose and to determine the ability of liver cells to repair potentially lethal damage (PLD) after neutron exposure. Hepatocyte reproductive survival was used as the biological end point in these studies and hepatocyte survival was determined with an in vivo transplantation clonogenic assay system. The estimated survival data for neutron exposed hepatocytes were best described by a single hit-single target model. In contrast to the results obtained with /sup 60/Co, hepatocytes exposed to neutrons are unable to repair PLD. The RBE value, when the reproductive survival was estimated 30 min after radiation exposure, is independent of neutron dose and equal to 1.6 +/- 0.1. In contrast, when the reproductive survival was estimated 24 hrs after radiation exposure, the RBE was found to increase with decreasing neutron dose and equal 4.2 +/- 0.5 at 50 cGy.

• Research Organization: Duke Univ. Medical Center, Durham, NC
• OSTI ID: 6864858
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:6; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL KILLING
COBALT 60
COBALT ISOTOPES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY RANGE
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
HADRONS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIVER CELLS
MAMMALS
MEV RANGE
MEV RANGE 10-100
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RATS
RBE
RECOVERY
REPAIR
RODENTS
SOMATIC CELLS
SURVIVAL CURVES
VERTEBRATES
YEARS LIVING RADIOISOTOPES