Relative biological effectiveness measurements using murine lethality and survival of intestinal and hematopoietic stem cells after Fermilab neutrons compared to JANUS reactor neutrons and /sup 60/Co gamma rays

Journal Article · Thu Nov 01 04:00:00 EST 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576350· OSTI ID:6250337

Hanson, W R; Crouse, D A; Fry, R J.M.; Ainsworth, E J

The relative biological effectiveness (RBE) of the 25-MeV (average energy) neutron beam at the Fermi National Accelerator Laboratory was measured using murine bone marrow (LD/sub 50/30/) and gut (LD/sub 50/6/) lethality and killing of hematopoietic colony forming units (CFU-S) or intestinal clonogenic cells (ICC). The LD/sub 50/30/ and LD/sub 50/6/ for mice exposed to the Fermilab neutron beam were 6.6 and 8.7 Gy, respectively, intermediate between those of JANUS neutrons and /sup 60/Co ..gamma.. rays. The D/sub 0/ values for CFU-S and ICC were 47 cGy and 1.05 Gy, respectively, also intermediate between the lowest values found for JANUS neutrons and the highest values found after /sup 60/Co ..gamma.. rays. The split-dose survival ratios for CFU-S at intervals of 1-6 hr between doses were essentially 1.0 for both neutron sources. The 3-hr split-dose survival ratios for ICC were 1.0 for JANUS neutrons, 1.85 for Fermilab neutrons, and 6.5 for /sup 60/Co ..gamma.. rays. The RBE estimates for LD/sub 50/30/ were 1.5 and 2.3 for Fermilab and JANUS neutrons, respectively. Based on LD/sub 50/6/, the RBEs were 1.9 (Fermilab) and 3.0 (JANUS). The RBEs for CFU-S D/sub 0/ were 1.4 (Fermilab) and 1.9 (JANUS) and for jejunal microcolony D/sub 0/ 1.4 (Fermilab) and 2.8 (JANUS).

• Research Organization: Argonne National Lab., IL
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6250337
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 100:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW CELLS
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
CONNECTIVE TISSUE CELLS
CRYPT CELLS
CYCLIC ACCELERATORS
DATA
DIGESTIVE SYSTEM
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
EXPERIMENTAL DATA
FAST NEUTRONS
FERMILAB ACCELERATOR
FERMIONS
GAMMA RADIATION
GASTROINTESTINAL TRACT
HADRONS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
JANUS REACTOR
LETHAL DOSES
LETHAL RADIATION DOSE
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RBE
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
RODENTS
SMALL INTESTINE
SOMATIC CELLS
STEM CELLS
SURVIVAL CURVES
SYNCHROTRONS
TANK TYPE REACTORS
THERMAL REACTORS
VERTEBRATES
WATER COOLED REACTORS
WATER MODERATED REACTORS
YEARS LIVING RADIOISOTOPES