Transplantation system for determining the clonogenic survival of parenchymal hepatocytes exposed to ionizing radiation
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:5363629
An in vivo transplantation technique has been developed which can be utilized to determine the reproductive survival of parenchymal hepatocytes exposed either in vitro or in vivo to both physical and chemical genotoxic agents. We have used this assay system to determine the survival of liver cells exposed to sparsely ionizing radiation. The D0 value of the survival curve was 249 rads and the extrapolation number was 1.2. These results indicate that hepatocytes irradiated while in the G0 phase are unable to accumulate sublethal damage to an appreciable extent if they are stimulated to undergo replication within 24 hr after the infliction of the damage.
- OSTI ID:
- 5363629
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 41:9 Pt 1; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CYCLE
CYTOLOGICAL TECHNIQUES
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DOSES
GLANDS
IN VIVO
IONIZING RADIATIONS
LIVER
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
SURVIVAL CURVES
TRANSPLANTS
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CYCLE
CYTOLOGICAL TECHNIQUES
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DOSES
GLANDS
IN VIVO
IONIZING RADIATIONS
LIVER
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
SURVIVAL CURVES
TRANSPLANTS