Radiation-induced mouse liver neoplasms and hepatocyte survival

Journal Article · Wed Oct 01 04:00:00 EDT 1986 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6989687

Di Majo, V; Coppola, M; Rebessi, S; Bassani, B; Alati, T; Saran, A; Bangrazi, C; Covelli, V

Transplantation of hepatocytes from CBA/Cne mice into the fat pads of isogeneic recipients has been used for the quantitative in vivo study of cell survival and risk of transformation after x-ray irradiation (1-7 Gy). A survival curve for liver cells was generated in vivo with a D0 of 3.08 Gy and an extrapolation number not significantly different from 1. Data on liver tumor incidence in whole-body irradiated CBA/Cne and C57BL/Cne X C/sub 3/H/HeCne (BC3F1) mice are also reported. A statistical analysis of trend in both cases proved a significant induction of tumors by x-rays mainly for doses above 2 Gy. The risk of transformation per surviving cell was estimated for both mouse strains. For CBA mice the data points suggested the presence of a linear component in the dose-effect curve at low doses, whereas for BC3F1 mice a quadratic expression appeared to provide a better description of the points from 1 to 6 Gy. The data of this study suggested that liver tumors can be induced by radiation in mouse strains with either a high or low spontaneous hepatoma incidence.

• Research Organization: ENEA C.R.E. Casaccia, Rome, Italy
• OSTI ID: 6989687
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 4; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GLANDS
IONIZING RADIATIONS
IRRADIATION
LIVER
LIVER CELLS
MAMMALS
MICE
NEOPLASMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SOMATIC CELLS
SURVIVAL TIME
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION