Dose-response relationship of radiation-induced harderian gland tumors and myeloid leukemia of the CBA/Cne mouse
Transplantation of harderian gland cells from CBA/-Cne mice into the fat pad of isogenic recipients was used for a quantitative in vivo study of cell survival and risk of transformation after x-ray irradiation (1-7 Gy). A survival curve for gland cells was generated in vivo with a D0 of 1.83 Gy and an extrapolation number of 7.23. Subsequently, the dose-response curve for lesions observed in nodules after cell transplantation was compared with that for lesions observed in glands irradiated in situ. A high incidence of epithelial hyperplasias with severe dysplasia was observed in transplantation nodules after x-irradiation. Gland tumors were significantly induced in whole-body irradiated animals; the tumors reached a maximum incidence after doses of 3 Gy. The risk of transformation per surviving cell was estimated both for dysplastic lesions and for tumors. These results approximated a dose-squared relationship in both cases, suggesting a common induction mechanism at the cellular level. Myeloid leukemia was observed at all doses in whole-body irradiated mice, and the maximum tumor incidence was reached at doses around 3 Gy.
- Research Organization:
- ENEA Centro Ricerche Energia Casaccia, Rome, Italy
- OSTI ID:
- 5650961
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Radiation-induced mouse liver neoplasms and hepatocyte survival
Correlations between the degree and type of forebrain malformations and the simultaneous neuro-oncogenic properties of ethylnitrosourea after diaplacental exposure in rats, alone and in combination with X-irradiation
Related Subjects
EYES
EXPERIMENTAL NEOPLASMS
LEUKEMIA
RADIOINDUCTION
DOSE-RESPONSE RELATIONSHIPS
MICE
RADIATION DOSES
RISK ASSESSMENT
SURVIVAL TIME
WHOLE-BODY IRRADIATION
X RADIATION
ANIMALS
BODY
BODY AREAS
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FACE
HEAD
HEMIC DISEASES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NEOPLASMS
ORGANS
RADIATIONS
RODENTS
SENSE ORGANS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals