Cadmium-resistant variant of the Chinese hamster (CHO) cell with increased metallothionein induction capacity
Journal Article
·
· Exp. Cell Res.; (United States)
The toxic trace metal Cd/sup 2 +/ has been used to select a variant (designated Cd/sup r/) of the Chinese hamster cell (line CHO) resistant to the growth-inhibitory and cytotoxic effects of Cd/sup 2 +/. Comparison of the relative capacities of these two cell types to induce specific low molecular weight Cd/sup 2 +/-binding proteins (metallothioneins) reveals that the Cd/sup r/ cell has an increased capacity to induce metallothionein and to sequester intracellular Cd/sup 2 +/ in metallothioneins. These results suggest that the greater competence of the Cd/sup r/ cell to induce metallothionein is a major factor in the Cd/sup 2 +/-resistant phenotype of the variant.
- Research Organization:
- Los Alamos Scientific Lab., NM
- OSTI ID:
- 6863556
- Journal Information:
- Exp. Cell Res.; (United States), Journal Name: Exp. Cell Res.; (United States) Vol. 124; ISSN ECREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparative studies of zinc metabolism in cultured Chinese Hamster cells wth differing metallothionein-induction capacities
Trace element damage assessment in mammalian cells: analysis of cellular resistance to cadmium-mediated toxicity using a CHO variant with increased metallothionein induction capacity. Progress report, July 1, 1977--December 31, 1978
Coordinate amplification of metallothionein I and II genes in cadmium-resistant Chinese hamster cells: implications for mechanisms regulating metallothionein gene expression
Journal Article
·
Mon Dec 31 23:00:00 EST 1979
· Biol. Trace Elem. Res.; (United States)
·
OSTI ID:6279335
Trace element damage assessment in mammalian cells: analysis of cellular resistance to cadmium-mediated toxicity using a CHO variant with increased metallothionein induction capacity. Progress report, July 1, 1977--December 31, 1978
Technical Report
·
Wed Jan 31 23:00:00 EST 1979
·
OSTI ID:6450618
Coordinate amplification of metallothionein I and II genes in cadmium-resistant Chinese hamster cells: implications for mechanisms regulating metallothionein gene expression
Journal Article
·
Thu Jan 31 23:00:00 EST 1985
· Mol. Cell. Biol.; (United States)
·
OSTI ID:6178403
Related Subjects
550400 -- Genetics
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CADMIUM
ELEMENTS
GENETIC EFFECTS
HAMSTERS
HETEROCYCLIC COMPOUNDS
MAMMALS
METALS
MUTANTS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RODENTS
STIMULATION
SURVIVAL CURVES
THIONINE
VERTEBRATES
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CADMIUM
ELEMENTS
GENETIC EFFECTS
HAMSTERS
HETEROCYCLIC COMPOUNDS
MAMMALS
METALS
MUTANTS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RODENTS
STIMULATION
SURVIVAL CURVES
THIONINE
VERTEBRATES