Antiinflammatory agents protect opossum esophagus during radiotherapy. [Cobalt 60]

Journal Article · Fri Oct 01 04:00:00 EDT 1982 · Dig. Dis. Sci.; (United States)

DOI:https://doi.org/10.1007/BF01316577· OSTI ID:6852908

Northway, M G; Eastwood, G L; Libshitz, H I; Feldman, M S; Mamel, J J; Szwarc, I A

Eighteen opossums received 2250 rad /sup 60/Co to the entire esophagus and lower esophageal sphincter. Animals received treatment with 600 mg aspirin, 25 mg/kg hydrocortisone, or saline before irradiation and twice daily for 1 week after irradiation. At 10 days postirradiation, animals were evaluated for signs of acute esophagitis by esophagoscopy and barium esophagram. Each animal was then killed and the esophagus removed and evaluated histologically. Animals treated with either aspirin or hydrocortisone had significantly milder esophagitis than control irradiated animals.

• Research Organization: Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
• OSTI ID: 6852908
• Journal Information: Dig. Dis. Sci.; (United States), Journal Name: Dig. Dis. Sci.; (United States) Vol. 27:10; ISSN DDSCD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLSALICYLIC ACID
ADRENAL HORMONES
ANALGESICS
ANIMALS
ANTIPYRETICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COBALT 60
COBALT ISOTOPES
CORTICOSTEROIDS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ESOPHAGUS
GAMMA RADIATION
GLUCOCORTICOIDS
HORMONES
HYDROCORTISONE
HYDROXY ACIDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
MAMMALS
MARSUPIALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PREGNANES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
STEROID HORMONES
STEROIDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES