Response of canine esophagus to intraoperative electron beam radiotherapy

Journal Article · Thu Sep 01 04:00:00 EDT 1988 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(88)90309-4· OSTI ID:7053085

Sindelar, W F; Hoekstra, H J; Kinsella, T J; Barnes, M; DeLuca, A M; Tochner, Z; Pass, H I; Kranda, K C; Terrill, R E

Tolerance of esophagus to intraoperative radiotherapy (IORT) was investigated in dogs. Thirteen adult foxhounds were subjected to right thoractomy, mobilization of the intrathoracic esophagus, and IORT to a 6 cm full-thickness esophageal segment using 9 MeV electrons at doses of 0, 2,000, or 3,000 cGy. Dogs were followed clinically and were evaluated at regular intervals after treatment with fiberoptic esophagoscopy, barium swallows, and postmortem histologic evaluations. One sham-irradiated control dog showed no abnormalities during follow-up of 24 months. Seven dogs receiving 2,000 cGy IORT showed transient mild dysphagia and mild esophagitis, but no clinically or pathologically significant complications. Five dogs receiving 3,000 cGy demonstrated severe ulcerative esophagitis within 6 weeks of treatment which progressed to chronic ulcerative esophagitis with stricture formation by 9 months following IORT. One 3,000 cGy dog died at 13 months from an esophageal perforation. On the basis of a pilot experience using 13 experimental animals, it was concluded that intact canine esophagus tolerates IORT well to doses of 2,000 cGy, but doses of 3,000 cGy pose serious and potentially lethal risks. The clinical application of IORT to the treatment of human intrathoracic neoplasms requiring esophageal irradiation should be approached with caution, particularly at doses exceeding 2,000 cGy.

• Research Organization: National Cancer Institute, Bethesda, MD (USA)
• OSTI ID: 7053085
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 15:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAMS
BODY
BODY AREAS
CHEST
DIGESTIVE SYSTEM
DOGS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTRON BEAMS
ESOPHAGUS
EXPERIMENTAL NEOPLASMS
LEPTON BEAMS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PARTICLE BEAMS
RADIATION DOSES
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
VERTEBRATES