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Opossum as an animal model for studying radiation esophagitis. [Gamma rays]

Conference · · Radiology; (United States)
OSTI ID:6254524
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Six opossums were evaluated as a possible animal model of radiation esophagitis. In a single exposure to the esophagus, four animals received /sup 60/Co radiation of various doses; two served as controls. Pre- and postirradiation evaluations using fiberoptic endoscopy, mucosal biopsy, barium esophagography, and manometry were performed. Esophagitis developed at one week in irradiated animals. Opossums receiving 17.5, 20, and 22.5 Gy (1,750; 2,000; and 2,250 rad) became anorexic one week postirradiation, and abnormal motility subsequently developed. The controls and the animal receiving 15 Gy (1,500 rad) remained normal. Histological changes in the irradiated opossum esophagus resembled those found in humans.
OSTI ID:
6254524
Conference Information:
Journal Name: Radiology; (United States) Journal Volume: 131:3
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BODY
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ESOPHAGUS
GAMMA RADIATION
INFLAMMATION
INJURIES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOCAL IRRADIATION
MAMMALS
MARSUPIALS
MINUTES LIVING RADIOISOTOPES
NECROSIS
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES