Opossum as an animal model for studying radiation esophagitis. [Gamma rays]
Six opossums were evaluated as a possible animal model of radiation esophagitis. In a single exposure to the esophagus, four animals received /sup 60/Co radiation of various doses; two served as controls. Pre- and postirradiation evaluations using fiberoptic endoscopy, mucosal biopsy, barium esophagography, and manometry were performed. Esophagitis developed at one week in irradiated animals. Opossums receiving 17.5, 20, and 22.5 Gy (1,750; 2,000; and 2,250 rad) became anorexic one week postirradiation, and abnormal motility subsequently developed. The controls and the animal receiving 15 Gy (1,500 rad) remained normal. Histological changes in the irradiated opossum esophagus resembled those found in humans.
- OSTI ID:
- 6254524
- Journal Information:
- Radiology; (United States), Vol. 131:3; Conference: 65. scientific assembly and annual meeting, Atlanta, GA, USA, 25 Nov 1979
- Country of Publication:
- United States
- Language:
- English
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ESOPHAGUS
DELAYED RADIATION EFFECTS
EARLY RADIATION EFFECTS
INFLAMMATION
RADIOINDUCTION
NECROSIS
RADIATION INJURIES
BIOLOGICAL MODELS
ACUTE IRRADIATION
COBALT 60
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
LOCAL IRRADIATION
MARSUPIALS
ACUTE EXPOSURE
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BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
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DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
INJURIES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
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VERTEBRATES
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560152* - Radiation Effects on Animals- Animals