Influence of fractionation schedules on the response of a rat brain tumor to therapy with BCNU and radiation
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The maximum dose of 1, 3 bis(2-chloroethyl)-1-nitrosourea (BCNU) that produced minimal toxicity after intraperitoneal administration 2, 3, or 5x/wk for 2 weeks was found to be 3.0, 2.5, or 2.0 mg/kg/treatment, respectively. BCNU toxicity appeared to be related to the total dose administered, which indicated little if any split-dose recovery. Deaths after whole brain irradiation resulted predominantly from starvation because of the inability of the irradiated rats to eat food pellets. When placed on a diet of soft mash, virtually all rats survived irradiation schedules of 520 rad/day 2x/wk for 2 wk; 433 rad/day 3x/wk for 2 wk; and 260 rad/day 5x/wk for 2 wk. There was no additional toxicity when these maximum doses of BCNU and radiation were combined in 2 week fractionation schemes. The 2x/wk and 3x/wk BCNU + radiation schedules, which employed the maximum tolerable doses of each agent, were as effective as the 5x/wk combination schedule in treating day 12 intracerebral 9L brain tumors.
- Research Organization:
- Univ. of Rochester Cancer Center, New York
- OSTI ID:
- 6852793
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:7; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
Similar Records
BCNU and x-ray therapy of intracerebral 9L rat tumors
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Brain tumor therapy: prospects for combining BCNU with conventional radiotherapy schedules
Conference
·
Sat Sep 01 00:00:00 EDT 1979
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5339143
Combination therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea and low dose rate radiation in the 9L rat brain tumor and spheroid models: implications for brain tumor brachytherapy
Journal Article
·
Fri Nov 30 23:00:00 EST 1984
· Neurosurgery; (United States)
·
OSTI ID:5777666
Brain tumor therapy: prospects for combining BCNU with conventional radiotherapy schedules
Journal Article
·
Sat Aug 01 00:00:00 EDT 1981
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5888320
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMALS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARBONIC ACID DERIVATIVES
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NEOPLASMS
NERVOUS SYSTEM
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SURVIVAL CURVES
TOXICITY
UREA
VERTEBRATES
X RADIATION
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMALS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARBONIC ACID DERIVATIVES
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NEOPLASMS
NERVOUS SYSTEM
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SURVIVAL CURVES
TOXICITY
UREA
VERTEBRATES
X RADIATION