BCNU and x-ray therapy of intracerebral 9L rat tumors

Conference · Sat Sep 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5339143

Barker, M; Deen, D F; Baker, D G

Combination therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and x-rays was applied to the 9L rat brain tumor model. BCNU alone (13.3 mg/kg) and x-rays alone (2,000 rad/whole brain)were given on day 16 postimplant. The two therapies were combined in three schedules with BCNU given 6 hours before, 6 hours after, and immediately preceding x-ray treatment. While either modality alone significantly increased survival, the combined therapies produced increased life spans (ILS) of 235 to 430%. The combined therapies also resulted in cure rates as high as 60%. Some toxicity was encountered as evidenced by interstitial pulmonary fibrosis when ''cured'' and treated non-tumor bearing animals were autopsied on day 122 or day 125.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5339143
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
EXTERNAL IRRADIATION
FIBROSIS
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
LUNGS
MAMMALS
MEDICINE
NEOPLASMS
NITROSO COMPOUNDS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RATS
RESPIRATORY SYSTEM
RODENTS
SIDE EFFECTS
THERAPY
VERTEBRATES
X RADIATION