Comparison of the CCNU and BCNU modification of the in vitro radiation response in 9L brain tumor cells of rats

Conference · Sat Sep 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5275272

Deen, D F; Williams, M E; Wheeler, K T

Rat brain tumor cells (9L) were exposed for 1 hr to combinations of 1,3-bis(2-chloroethyl)-1-nitrosourea (CCNU, 3 ..mu..g/ml) or 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU, 3 ..mu..g/ml) and graded doses of radiation (0-20 Gy). BCNU significantly modified the shoulder of the x-ray survival curve, especially when given 15 hr before irradiation. CCNU modified the shoulder of the x-ray curve to a lesser extent than an equivalent concentration of BCNU. Dose enhancement ratios (DER's) in the shoulder region for time intervals from 5 to 23 hr were larger for the BCNU-radiation combination than for the CCNU-radiation combination. At all other time intervals studied, DER's in the shoulder region for the BCNU-radiation combination were at least as large as those obtained for the CCNU-radiation combination. These results suggest that BCNU-radiation protocols may elicit a better clinical response than CCNU-radiation protocols.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5275272
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMALS
NERVOUS SYSTEM
NITROSO COMPOUNDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
TUMOR CELLS
VERTEBRATES
X RADIATION