Brain tumor therapy: prospects for combining BCNU with conventional radiotherapy schedules

Journal Article · Sat Aug 01 04:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90160-7· OSTI ID:5888320

Wheeler, K T; Kaufman, K

When the largest doses of BCNU that could be given 3 times per week (2.5 mg/kg) or 2 times per week (3.0 mg/kg) were used in combination with five 260 rad fractions of radiation per week to treat intracerebral 9L tumors over a 2 week period, neither combination schedule was as effective as the schedule where 2.0 mg/kg of BCNU was delivered 5 times per week, 16 hr before each daily radiation treatment. In a previously published report using this same tumor system, the maximum tolerable dose of BCNU administered 16 hr before the maximum tolerable dose of radiation 2 or 3 times per week was equally effective as the daily combination schedule. Therefore, our data suggest that the optimum combination of BCNU and radiation for treating human brain tumors may require the use of unconventional radiotherapy schedules like those used in several radiosensitizer protocols rather than conventional daily fractionation schedules.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 5888320
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IONIZING RADIATIONS
MAMMALS
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION DOSES
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RATS
RODENTS
THERAPY
TUMOR CELLS
VERTEBRATES