Response of a rat brain tumor to fractionated therapy with low doses of BCNU and irradiation
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5236336
When intracerebral 9L tumors in male Fischer 344 rats were treated with daily fractions of BCNU and x-rays, 5 days per week for 2 weeks, the following were found: (1) there was a significant increase in the life-span of rats treated with the combination treatment schemes over that observed for rats treated with the single agent schemes, (2) the increase in life-span in the combination treatments was critically dependent on the time interval between the BCNU and x-ray treatments, and (4) the results of the optimum combination treatment were not critically dependent on the tumor size or growth state.
- Research Organization:
- Univ. of Rochester Cancer Center, NY
- OSTI ID:
- 5236336
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
MAMMALS
NEOPLASMS
NERVOUS SYSTEM
NITROSO COMPOUNDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
VERTEBRATES
X RADIATION
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
MAMMALS
NEOPLASMS
NERVOUS SYSTEM
NITROSO COMPOUNDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SURVIVAL CURVES
TIME DEPENDENCE
VERTEBRATES
X RADIATION