Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

The effect of radiation on normal human CNS as detected by NMR spectroscopy

Journal Article · · International Journal of Radiation Oncology, Biology and Physics; (United States)
;  [1]; ;  [2]
  1. Univ. of Alberta, Edmonton (Canada)
  2. Cross Cancer Institute, Edmonton (Canada)
+ Show Author Affiliations

In a prospective study, proton ([sup 1]H) and phosphorus ([sup 31]P) nuclear magnetic resonance spectroscopy were used to search for effects of brain tumor radiotherapy on normal human central nervous system. Phosphorus spectroscopy data at 1.5 T seems to suggest that any radiation induced damage that may occur as a result of therapeutic brain irradiation, does not alter the relative concentrations of phosphorus metabolites or the intracellular pH beyond the limits of normal variation (approximately [+-]20%). Proton spectroscopy, on the other hand, detects post radiation changes in the ratios of certain nuclear magnetic resonance visible metabolites following radiotherapy, particularly choline/N-acetylaspartate, and especially in regions of brain receiving high doses of radiation. Such changes may be indicative of the release of membrane bound choline during radiation induced demyelination of brain. Of interest, the authors have found elevated metabolite ratios of [sup 31]P in normal central nervous system prior to radiotherapy, which persisted throughout the time span of the study in both the ipsilateral and contralateral cerebral hemispheres. 30 refs., 3 figs., 2 tabs.

OSTI ID:
6850928
Journal Information:
International Journal of Radiation Oncology, Biology and Physics; (United States), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (United States) Vol. 25:4; ISSN IOBPD3; ISSN 0360-3016
Country of Publication:
United States
Language:
English

Similar Records

NMR imaging and spectroscopy of the mammalian central nervous system after heavy ion radiation
Technical Report · Sat Sep 01 00:00:00 EDT 1984 · OSTI ID:6268623
Spatially localized sup 1 H NMR spectra of metabolites in the human brain
Journal Article · Mon Feb 29 23:00:00 EST 1988 · Proceedings of the National Academy of Sciences of the United States of America; (USA) · OSTI ID:6896403
Brain nuclear magnetic resonance imaging enhanced by a paramagnetic nitroxide contrast agent: preliminary report. [Dogs]
Journal Article · Mon Oct 31 23:00:00 EST 1983 · AJR, Am. J. Roentgenol.; (United States) · OSTI ID:5551387

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY