Spatially localized sup 1 H NMR spectra of metabolites in the human brain
- Univ. of Alberta, Edmonton (Canada)
- Yale Univ., New Haven, CT (USA)
- Yale School of Medicine, New Haven, CT (USA)
Using a surface coil, the authors have obtained {sup 1}H NMR spectra from metabolites in the human brain. Localization was achieved by combining depth pulses with image-selected in vivo spectroscopy magnetic field gradient methods. {sup 1}H spectra in which total creatine (3.03 ppm) has a signal/noise ratio of 95:1 were obtained in 4 min from 14 ml of brain. A resonance at 2.02 ppm consisting predominantly of N-acetylaspartate was measured relative to the creatine peak in gray and white matter, and the ratio was lower in the white matter. The spin-spin relaxation times of N-acetylaspartate and creatine were measured in white and gray matter and while creatine relaxation times were the same in both, the N-acetylaspartate relaxation time was longer in white matter. Lactate was detected in the normoxic brain and the average of three measurements was {approx}0.5 mM from comparison with the creatine plus phosphocreatine peak, which was assumed to be 10.5 mM.
- OSTI ID:
- 6896403
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 85:6; ISSN 0027-8424
- Country of Publication:
- United States
- Language:
- English
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NMR SPECTRA
ASPARTIC ACID
CREATINE
LACTATES
MAN
PROTONS
RELAXATION TIME
SPIN-SPIN RELAXATION
AMINO ACIDS
ANIMALS
BARYONS
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
ELEMENTARY PARTICLES
FERMIONS
HADRONS
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MAMMALS
NERVOUS SYSTEM
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics