Spatially localized sup 1 H NMR spectra of metabolites in the human brain

Journal Article · Mon Feb 29 23:00:00 EST 1988 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.85.6.1821· OSTI ID:6896403

Hanstock, C C ^[1]; Rothman, D L; Jue, T; Shulman, R G ^[2]; Prichard, J W ^[3]

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1. Univ. of Alberta, Edmonton (Canada)
2. Yale Univ., New Haven, CT (USA)
3. Yale School of Medicine, New Haven, CT (USA)

Using a surface coil, the authors have obtained {sup 1}H NMR spectra from metabolites in the human brain. Localization was achieved by combining depth pulses with image-selected in vivo spectroscopy magnetic field gradient methods. {sup 1}H spectra in which total creatine (3.03 ppm) has a signal/noise ratio of 95:1 were obtained in 4 min from 14 ml of brain. A resonance at 2.02 ppm consisting predominantly of N-acetylaspartate was measured relative to the creatine peak in gray and white matter, and the ratio was lower in the white matter. The spin-spin relaxation times of N-acetylaspartate and creatine were measured in white and gray matter and while creatine relaxation times were the same in both, the N-acetylaspartate relaxation time was longer in white matter. Lactate was detected in the normoxic brain and the average of three measurements was {approx}0.5 mM from comparison with the creatine plus phosphocreatine peak, which was assumed to be 10.5 mM.

• OSTI ID: 6896403
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 85:6; ISSN PNASA; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
ASPARTIC ACID
BARYONS
BODY
BRAIN
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CREATINE
ELEMENTARY PARTICLES
FERMIONS
HADRONS
LACTATES
MAGNETIC RESONANCE
MAMMALS
MAN
METABOLITES
NERVOUS SYSTEM
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTONS
RELAXATION
RELAXATION TIME
RESONANCE
SPECTRA
SPIN-SPIN RELAXATION
VERTEBRATES