Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease

Journal Article · Sun Apr 01 04:00:00 EDT 1990 · Magnetic Resonance in Medicine; (USA)

DOI:https://doi.org/10.1002/mrm.1910140115· OSTI ID:6717931

Arnold, D L; Matthews, P M; Francis, G; Antel, J ^[1]

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1. McGill Univ., Quebec (Canada)

Image localized, water-suppressed proton magnetic resonance spectra were obtained from affected brain in patients with multiple sclerosis. In patients with moderate to severe chronic disease, spectra revealed a decreased ratio of N-acetylaspartate to creatine resonance intensities. A normal ratio was obtained from a large recently symptomatic MRI plaque that resolved without sequelae. We propose that the observed metabolite changes can be useful as an index of irreversible CNS injury.

• OSTI ID: 6717931
• Journal Information: Magnetic Resonance in Medicine; (USA), Journal Name: Magnetic Resonance in Medicine; (USA) Vol. 14:1; ISSN 0740-3194; ISSN MRMEE
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
ASPARTIC ACID
BARYONS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTARY PARTICLES
FERMIONS
HADRONS
IN VIVO
MAGNETIC RESONANCE
MAMMALS
MAN
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTONS
RESONANCE
VERTEBRATES