Proton magnetic resonance spectroscopy in multiple sclerosis

Journal Article · Thu Nov 01 04:00:00 EST 1990 · Neurology; (USA)

DOI:https://doi.org/10.1212/WNL.40.11.1764· OSTI ID:6170656

Wolinsky, J S; Narayana, P A; Fenstermacher, M J ^[1]

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1. Univ. of Texas Health Science Center, Houston (USA)

Regional in vivo proton magnetic resonance spectroscopy provides quantitative data on selected chemical constituents of brain. We imaged 16 volunteers with clinically definite multiple sclerosis on a 1.5 tesla magnetic resonance scanner to define plaque-containing volumes of interest, and obtained localized water-suppressed proton spectra using a stimulated echo sequence. Twenty-five of 40 plaque-containing regions provided spectra of adequate quality. Of these, 8 spectra from 6 subjects were consistent with the presence of cholesterol or fatty acids; the remainder were similar to those obtained from white matter of normal volunteers. This early experience with regional proton spectroscopy suggests that individual plaques are distinct. These differences likely reflect dynamic stages of the evolution of the demyelinative process not previously accessible to in vivo investigation.

• OSTI ID: 6170656
• Journal Information: Neurology; (USA), Journal Name: Neurology; (USA) Vol. 40:11; ISSN 0028-3878; ISSN NEURA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
BARYONS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTARY PARTICLES
FERMIONS
HADRONS
LIPIDS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NMR IMAGING
NUCLEONS
ORGANIC COMPOUNDS
ORGANS
PROTONS