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Acute toxicity of the hydrolysis products of uranium hexafluoride (UF/sub 6/) when inhaled by the rat and guinea pig. Final report

Technical Report ·
OSTI ID:6848815
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This report presents the experimental animal data base from which human health consequences may be predicted from exposures mimicing accidental discharges of uranium hexafluoride (UF/sub 6/) in the uranium industry. Rats or guinea pigs were exposed for two, five, or ten minutes duration to air having 0.44 g U/m/sup 3/ + 0.16 g HF/m/sup 3/ to 276.67 g U/m/sup 3/ + 94.07 g HF/m/sup 3/. Survivors of each exposure were observed for 14 days for signs of U or HF intoxication. Selected animals were necropsied and samples of major organs were studied histopathologically. When enriched UF/sub 6/ (94 percent /sup 235/U) was used, the urine and feces from each animal were measured daily for U content. Selected samples of urine were bioassayed in order to trace the course of renal injury during the two week postexposure period. 28 references, 51 figures, 23 tables.

Research Organization:
Rochester Univ., NY (USA). Medical Center
DOE Contract Number:
AC05-84OT21400
OSTI ID:
6848815
Report Number(s):
K/SUB-81-9039/3; ON: DE84011539
Country of Publication:
United States
Language:
English

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Related Subjects

560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BODY
CLEARANCE
DATA
DOSE-RESPONSE RELATIONSHIPS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FLUORIDES
FLUORINE COMPOUNDS
GUINEA PIGS
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HISTOLOGY
HYDROFLUORIC ACID
HYDROGEN COMPOUNDS
INFORMATION
INHALATION
INORGANIC ACIDS
INTAKE
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LUNGS
MAMMALS
MINUTES LIVING RADIOISOTOPES
MORTALITY
NUCLEI
NUMERICAL DATA
ORGANS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
TRACER TECHNIQUES
URANIUM 235
URANIUM COMPOUNDS
URANIUM FLUORIDES
URANIUM HEXAFLUORIDE
URANIUM ISOTOPES
URANYL COMPOUNDS
URANYL FLUORIDES
VERTEBRATES
YEARS LIVING RADIOISOTOPES